R&D Scientist III, Algorithm Developer

Position Summary 

This position requires thorough documentation of analytical methods, validation studies, and pipeline updates in technical reports, supporting both internal development and regulatory needs. The R&D Scientist will work collaboratively with cross functional teams, including assay development, bioinformatics, and quality groups.  

Candidates should hold a Ph.D. in Bioinformatics, Computational Biology, Genomics, Computer Science, or a related field, or an M.S. with 3+ years of relevant experience. Required expertise includes hands on‑ experience with NGS data analysis, particularly sequencing performance metrics, as well as strong programming skills in Python and/or R. 

Key Responsibilities 

• Perform in-depth analytical analysis of NGS sequencing data to evaluate sequencing performance metrics and support assay development  

• Validate and verify computational algorithms used within NGS analysis pipelines  

• Support NGS panel design activities, including analytical assessment and quality considerations  

• Conduct end-to-end validation of NGS analysis pipelines to ensure accuracy, reproducibility, and robustness  

• Support quality assurance efforts through data review, troubleshooting, and performance monitoring  

• Document analytical methods, validation studies, and pipeline updates in clear, well-structured technical reports  

• Collaborate with cross functional teams, including assay development, bioinformatics, and quality, to support R&D objective 

Required Qualifications 

• Ph.D. in Bioinformatics, Computational Biology, Genomics, Computer Science, or a related field; or M.S. with 3+ years of relevant experience  

• Hands‑on experience with NGS data analysis, including evaluation of sequencing performance metrics and assay quality  

• Experience validating computational algorithms or bioinformatics analysis pipelines  

• Proficiency in Python and/or R for data analysis and pipeline development  

• Strong analytical, documentation, and collaboration skills within a cross functional‑ R&D environment 

Preferred Qualifications 

• Preferred experience with Linux/HPC, Docker containerization, Nextflow workflow development, GitHub-based software engineering, and Python/Groovy programming. Familiarity with cloud platforms and NGS data formats (FASTQ, BAM, VCF), along with CI/CD, workflow automation, troubleshooting, and developing reproducible bioinformatics pipelines. 

• Knowledge of clinical genomics applications, including NIPT or cancer genomics  

• Experience or familiarity with pharmacogenomics (PGx) and complex variant analysis  

• Exposure to rare disease genomics and germline variant analysis