Director, Medicinal Chemistry

About Magnet Biomedicine

Magnet is a biotechnology company pioneering the discovery of oral molecular glues - small molecules that induce proximity between proteins to modulate their function. Our proprietary TrueGlue(TM) platform is designed to address hard-to-drug targets across cancer and immune-mediated diseases.

With support from ARCH Venture Partners, Newpath Partners, Taiho Ventures, and Eli Lilly, Magnet is advancing internal programs in oncology, immunology, and inflammation. Magnet has also entered into a collaboration and license agreement with Eli Lilly to discover, develop, and commercialize specific molecular glue therapeutics in oncology.

Position Summary

We are seeking an experienced medicinal chemist with a deep knowledge of medicinal and synthetic chemistry and a proven track record of leading and driving drug discovery programs to preclinical candidate selection to join our team at Magnet Biomedicine.

Responsibilities

• Lead multi-disciplinary drug discovery project teams from hit identification to candidate selection.
• Coordinate, lead, and manage internal and external chemistry teams, employing modern synthetic and parallel chemistry approaches and techniques.
• Formulate medicinal chemistry plans and strategies to drive molecular optimization by applying structure-based drug design, property predictions, computational, and modeling approaches.
• Employ modern visualization approaches to interpret and analyze complex biological and molecular data.
• Collaborate closely within cross-functional teams and foster cross-disciplinary relationships to advance project and company goals.
• Guide, manage, motivate, mentor, and support reports toward company goals. 
• Lead by example and positively influence the organization. 

Qualifications

• Ph.D. in Organic Chemistry with 7+ years of experience or Masters in Chemistry and 10+ years of experience and leadership in small molecule drug discovery
• Strong track record of creativity and problem-solving in medicinal and organic chemistry demonstrated by publications and patents.
• Effective people manager with 4+ years leading, coaching and enabling high performing teams.
• Ability to solve complex multiparametric problems, utilize computational and empirical data to drive molecular optimization, and possess working knowledge of adjacent fields critical to drug discovery and development, including but not limited to ADMET, in vitro and in vivo pharmacology, and CMC.
• Experience working with external CRO partners, BRo5 optimization, and molecular glues desired, but not necessary.
• Strong interpersonal, written, and oral communication skills.
• Self-motivated, adaptable, and able to thrive in a dynamic, interdisciplinary environment.